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EVKEEZA®: evinacumab for injection

EVKEEZA®: evinacumab for injection

Your infusion

15 mg/kg

Your doctor will work out how much EVKEEZA to give you. The amount will depend on your weight. The recommended dose is 15 milligrams for every kilogram you weigh.

60 minutes every 4 weeks

EVKEEZA is given to you by your doctor or nurse as a drip into a vein (‘intravenous IV line’) over 60 minutes. You will be given EVKEEZA once every 4 weeks.

Your healthcare professional may slow down your infusion rate, temporarily stop, or permanently stop treatment with EVKEEZA if you have certain side effects.

Your healthcare professional may prescribe other cholesterol-lowering medicines to use with EVKEEZA. Use the other prescribed medicines exactly as your healthcare professional tells you to.

Missed dose? If you miss any infusion appointments, call your healthcare professional as soon as possible to reschedule.

  1. Preparing for the infusion

    • Discuss with your healthcare professional where you will receive your infusion
    • Talk to your healthcare professional about the importance of hydration, especially if you have any medical restrictions that limit fluids
    • Hydration (drinking water) can make it easier to find difficult-to-access veins
    • Dress in comfortable clothes that allow access to your arm (room temperature may vary)
    • Consider bringing a book, music or tablet device for entertainment
    • For caregivers, you may want to come prepared with ways to keep your child occupied during treatment

  2. Before the infusion

    • Your healthcare professional may ask you questions about your general health
    • You may receive a simple health assessment

  3. During the infusion

    • EVKEEZA will be delivered through a needle put into a vein in your arm
    • The infusion lasts approximately 60 minutes
    • A healthcare professional will monitor you
    • Alert a healthcare professional immediately if you have any adverse reactions

  4. After the infusion

    • You will be monitored for side effects after your EVKEEZA infusion
    • Follow your healthcare team’s post-infusion instructions
    • Schedule a follow-up visit with your healthcare professional
    • Call your healthcare professional if you experience any reactions or unusual symptoms

What is EVKEEZA used for?

EVKEEZA (evinacumab for injection) is used to treat adults and children aged 5 years and older with very high cholesterol caused by a condition called homozygous familial hypercholesterolemia (HoFH). EVKEEZA is used with a low-fat diet and other medicines to bring down cholesterol levels.

Do not use EVKEEZA if:

  • You are allergic to evinacumab or any of the other ingredients in this medicine.

To help avoid side effects and ensure proper use, talk to your healthcare professional before you take EVKEEZA. Talk about any health conditions or problems you may have, including:

  • If you are pregnant, think you might be pregnant, or plan to become pregnant, ask your healthcare professional for advice before taking EVKEEZA. EVKEEZA may harm your unborn baby. Tell your healthcare professional if you become pregnant while using EVKEEZA. For people who are able to become pregnant:
    • Your healthcare professional may do a pregnancy test before you start treatment with EVKEEZA.
    • You should use an effective method of birth control during treatment and for at least 5 months after the last dose of EVKEEZA. Talk to your healthcare professional about birth control methods that you can use during this time.
  • If you are breastfeeding or plan to breastfeed, ask your healthcare professional for advice before you are given EVKEEZA. It is not known if EVKEEZA passes into your breast milk. You and your healthcare professional should decide if you will receive EVKEEZA or breastfeed.

Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements, or alternative medicines.

  • Studies to test how EVKEEZA interacts with other drugs have not been done.

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