EVKEEZA is used with a low‑fat diet and other medicines to bring down cholesterol levels in adults and children aged 5 years and older with very high cholesterol caused by HoFH.
What is EVKEEZA and how does it work?
Evinacumab, the active substance in EVKEEZA, attaches to a protein called ANGPTL3 and blocks its effects. When evinacumab blocks the effects of ANGPTL3, the level of LDL cholesterol in the blood is reduced and problems caused by high LDL cholesterol levels may also be reduced.
That’s how EVKEEZA can lower cholesterol levels and help manage HoFH along with a low-fat diet.
What’s in EVKEEZA?
The medicinal ingredient is evinacumab and non-medicinal ingredients include: L-arginine hydrochloride, L-histidine, L-histidine monohydrochloride monohydrate, L-proline, polysorbate 80, and water for injection, USP.
Do not use EVKEEZA if:
- You are allergic to evinacumab or any of the other ingredients in this medicine
What are the possible side effects?
Talk to your doctor or nurse if you experience any side effects during or after your infusion.
If you are pregnant, think you might be pregnant, or plan to become pregnant, ask your healthcare professional for advice before taking EVKEEZA. EVKEEZA may harm your unborn baby. Tell your healthcare professional if you become pregnant while using EVKEEZA
| Possible side effects | Uncommon but serious side effects |
|---|---|
|
Anaphylaxis (symptoms may include swelling of the lips, tongue, or throat that make it difficult to swallow or breathe, and may also include wheezing, feeling dizzy or fainting) If you experience these symptoms, stop taking EVKEEZA and get immediate medical help. |
These are not all the possible side effects you may have when taking EVKEEZA. If you experience any side effects not listed here, tell your healthcare professional.
Learn about your EVKEEZA infusion
